Side Effects of Donnatal belladonna phenobarbital: Interactions & Warnings - Join The Lights

Belladonna alkaloids and methscopolamine both decrease cholinergic effects/transmission. Phenobarbital increases and methamphetamine decreases sedation. Phenobarbital will decrease the level or effect of methadone by affecting hepatic/intestinal tony guacamole food truck enzyme CYP3A4 metabolism. Phenobarbital increases and metaproterenol decreases sedation. Phenobarbital will decrease the level or effect of mestranol by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Ibuprofen IVphenobarbital will decrease the level or effect of ibuprofen IV by affecting hepatic enzyme CYP2C9/10 metabolism. Ibuprofenphenobarbital will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Griseofulvinphenobarbital decreases levels of griseofulvin by inhibition of GI absorption. Galantaminephenobarbital will decrease the level or effect of galantamine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Furosemidephenobarbital decreases levels of furosemide by inhibition of GI absorption.

Belladonna alkaloid combinations and phenobarbital are used to relieve cramping pains in conditions such as irritable bowel syndrome and spastic colon. They also are used with other medicine to treat ulcers. These medicines decrease the motion of the stomach and intestines and the secretion of stomach fluids, including acid. By blocking acetylcholine, belladonna alkaloids relax intestinal muscles, slow passage of digesting food through the intestines, and reduce gastric secretion.

If unable to avoid, double current pralsetinib dose starting on Day 7 of coadministration with strong CYP3A inducer. After inducer has been discontinued for at least 14 days, resume previous pralsetinib dose. Phenobarbital will decrease the level or effect of pimavanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration if possible.

Phenobarbital will decrease the level or effect of quazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Propylhexedrinephenobarbital increases and propylhexedrine decreases sedation. Progesterone, naturalphenobarbital will decrease the level or effect of progesterone, natural by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Progesterone micronizedphenobarbital will decrease the level or effect of progesterone micronized by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Primaquinephenobarbital will decrease the level or effect of primaquine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Phenobarbital will decrease the level or effect of prednisone by P-glycoprotein efflux transporter.

Effect of interaction is not clear, use caution. Phenobarbital will decrease the level or effect of polatuzumab vedotin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Polatuzumab undergoes catabolism to small peptides, amino acids, monomethyl auristatin E , and unconjugated MMAE-related catabolites. MMAE is a CYP3A4 substrate.